1. Esagramma is a Social Cooperative, based in Milan, Italy. It was incorporated in 1999, developed from the rehabilitative and educational experience of Laboratorio di Musicologia Applicata, a voluntary organization established in 1985. 2. Subjects of Esagramma are young people and adults with intellectual and developmental disabilities (autism, cognitive and relational disabilities, genetic syndromes …). 3. The educational and therapeutic methods available are unique in Europe and are based on the original OrchestralMusicTherapy®, TryTheOrchestra®, and MusicVirtualOpera® methods, together with a wide array of supporting measures based on multimedia communication. 4. The Esagramma Symphony Orchestra, comprised of youths who have attended three-year basic and six-year specializing courses, and professional musicians, is the most “visible” activity. The musicians come from different Italian counties and centers that use the methods (Milano, Bergamo, Novara, Messina, Piacenza, Brescia, Darfo Boario Terme, Senago, and Borgomanero). 5. The Orchestra’s repertory includes orchestral arrangements of operas by Stravinsky, Dvòrak, Mahler, Gershwin, Beethoven, Bartòk, Mussorgsky, Saint-Saens, Grieg, Shostakovich, Sequeri and many more. The Esagramma Symphony Orchestra developed several concerts for famous Italian theatres, including Rome in the presence of Pope John Paul II and Loreto in the presence of Pope Benedict XVI. 6. On the occasion of the European Year of People with Special Needs, the orchestra was invited by European Parliament to perform in Brussels (Belgium) on November 2003, to present its methodologies and to perform at International Festivals in Dortmund (Germany) in 2010, in Pecs (Hungary) in 2011, in Linz (Austria) in 2012, in Wahington DC (USA) in 2013. 7. Esagramma is an Excellent Educational Centre of the Lombardy Region for educators, psychologists, doctors and musicians, which provides professional updating and specialization courses and a Master in OrchestralMusicTherapy®, TryTheOrchestra®, Multimedia Communication, and MusicVirtualOpera®.